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Lower levels of IGF-1 and growth hormone in older adults have been linked with (5, 14): increased fat mass increased cardiovascular risk decreased muscle mass and strength lower cognitive function lower bone density limited joint mobility Several of these traits are seen in frail older adults

doi: 10.3389/fneur.2025.1561000 Received 15 January 2025 Accepted 17 March 2025 Published 02 April 2025 Volume 16 - 2025 Edited by Claudia Altamura, Fondazione Policlinico Campus Bio-Medico, Italy Reviewed by Emel Ur Ozcelik, Istanbul University, Trkiye Adina Maria Roceanu, Bucharest University Emergency Hospital, Romania Updates Copyright 2025 Sun, Chen, Song, Gao and Xu

[37] [38] Chronic consumption of paracetamol is in many cases not of benefit, [25] and may result in abnormal liver function tests, and higher doses may lead to toxicity, including liver failure

Lipid encapsulation shields the peptide through the stomach