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Intestinal villi are damaged due to apoptosis of epithelial cells (126), and intestinal mast cells may act as a reservoir of inflammatory factors, activating the release of large quantities of inflammatory factors after ECMO initiation (127)

PMID: 33473342 11 Treatments of trimethylaminuria: where we are and where we might be heading

However, key impurities, such as Aspartate isomerization to isoAsp or racemization (D-amino acid formation), have the same mass and cannot be distinguished by mass alone

Among these factors, dysregulation of LDL-C and HDL-C levels is a fundamental driver of CVD pathogenesis and progression