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Oxidative stress mediates collateral sensitivity to tamoxifen Earlier reports have shown that heightened P-gp ATPase leads to selective decrease in cellular ATP level and a rise in reactive oxygen species (ROS), likely due to higher electron leak from mETC though enhanced oxidative phosphorylation [15, 16]

Halldin CB, Paoli J, Sandberg C, Ericson MB, Wennberg AM

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The retroviruses can generate human CNS symptoms that closely resemble MS

L-carnitine deficiency, accompanied as mentioned earlier by a slight increase in lactate and significant increases in alanine and ammonia, is a symptom of mitochondrial dysfunction