Iron dyshomeostasis in glial cellseven in the absence of cell deathcontributes to the vicious cycle: iron-loaded microglia directly secrete IL-1 and IL-18 to fuel neuroinflammation (Ryan et al., 2023), while reactive astrocytes release hepcidin and pro-inflammatory cytokines, which elevate neuronal iron load and sensitize neurons to ferroptosis (Xiong et al., 2016

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choline helps distribute cholesterol and prevent it from being deposited in one part of the body
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Gibellini L, Pinti M, Nasi M, De Biasi S, Roat E, Bertoncelli L, Cossarizza A (2010) Interfering with ROS metabolism in cancer cells: the potential role of quercetin