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10.1038/nrgastro.2016.107 Nat

Highlight: structural insights into nonribosomal peptide enzymatic assembly lines

For example, emerging protein targets like IL-4, IL-10, IL-15, IL-17, IL-18, IL-23, interleukin-1 receptor-associated kinase (IRAK)-4 have been revealed to have a strong implication with innate and adaptive immune response in RA ( Protein Targets for Treatment of Rheumatoid Arthritis Currently, many agents aiming at various protein targets have been explored and tested to ease the progression of RA, and some agents have been used in the clinic to treat RA patients ( Table 1 )

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They have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease