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The beneficial effect of TZT in T2DM and obesity is related to the direct activation of GIP and GLP-1 receptors with subsequent improvement of insulin sensitivity and reduction of bodyweight (Chavda et al
Furthermore, hypoglycemic agents such as pioglitazone and empagliflozin exhibit beneficial effects on liver tissue outcomes, such as reducing liver fat content and improving liver fibrosis (Jee et al., 2025
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[DOI] [PubMed] [Google Scholar] 24.Frias JP, et al
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