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Like other unsaturated phospholipid, cholesterol is intrinsically susceptible to peroxidation upon oxidative stress, which has been suggested to lead to damage of membrane integrity and function 25

Meller, N., Liu, Y

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For Aplnr-CreERT2 -controlled Flt4 loss-of-function experiments, Flt4 i Aplnr KO ( Flt4 lox/lox Aplnr-CreERT2 tg/+ ) embryos were compared with control littermates ( Flt4 lox/lox Aplnr-CreERT2 +/+ )