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Summary Takeaway Messages Despite the ability of GLP-1s to produce significant weight reduction and related health benefits, challenges such as GI side effects, risk of nutrient inadequacies, loss of muscle and bone mass, high costs, frequent discontinuation, and weight regain limit the use of these drugs for long-term success in individuals and populations

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A study investigated whether weight loss was sustained better one year after termination of a GLP-1, supervised exercise program, or combined for one year

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