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This study showed effects at very low concentrations (picomolar to nanomolar), which is encouraging for topical application

Journal of Trauma-Injury Infection and Critical Care 68(5):12571263

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It is of great interest for its effects and ability to induce sleep, especially in chronic insomnia, release pain, reduce oxidative stress, enhance muscle building, normalize of myocardial contractility, and is also being investigated as a possible agent in the treatment of depressive disorder and withdrawal symptoms