Selection of candidate mutants for functional validation Candidate variants were further screened for their prevalence in the TCGA patient population
Transl Psychiatry (2012) 2:e134.10.1038/tp.2012.61 24 TierneyEBukelisIThompsonREAhmedKAnejaAKratzLet alAbnormalities of cholesterol metabolism in autism spectrum disorders
Aged HSCs exhibit reduced self-renewal and repopulation capacity, a myeloid bias, and an increase in their frequency, while proteostatic mechanisms are compromised concomitant with chronic low-grade inflammation 11,12,13
A plethora of PASC clinical symptoms and related metabolic impairments indicate an involvement of various pathophysiological mechanisms originating from virus-induced HMRD
In particular, the relevance of the ATB 0,+ -mediated carnitine transport, in patients with PCD, may be explained considering that this protein is highly expressed in the intestine (Figure 2)