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Batch-to-batch variation is minimal, which matters for our longitudinal work

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Tariq, K

Trials commonly began at a low once-weekly dose (around 0.25 mg) and escalated in roughly 4-week steps, with 2.4 mg once weekly being the most-studied maintenance example and doses up to 4.5 mg examined in dose-finding work

At this concentration, the risk of coma, respiratory depression, and death increases sharply