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In addition, the supplementation of selenium, alone or together with vitamin E, did not show any benefits regarding the risk of prostate, lung, or colorectal cancers after 5.5 years of follow-up (86, 87)

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doi: 10.1016/j.fbio.2020.100875

Because GH and IGF-1 promote protein synthesis and lipolysis, these hormonal changes provide a plausible mechanistic basis for modest increases in lean body mass, improved recovery and support for fat loss seen in clinical and observational contexts, but robust controlled trials explicitly measuring those endpoints are still lacking