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Pre-existing neuropathy The case of the 75-year-old man with baseline neuropathy who developed severe allodynia on tirzepatide suggests that pre-existing nerve damage may create vulnerability

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"The results with semaglutide alone are encouraging and suggest a potential new treatment option for a group of patients who previously had very few." The Phase II trial followed about 700 adults with biopsy-confirmed MASH and moderate to advanced liver scarring, including participants who had already developed early cirrhosis

There havent been enough studies in humans to be certain how the drug might affect the fetus