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Butyrate is the primary energy source for colonocytes, as it strengthens tight junction proteins (zona occludens-1 (ZO-1) and claudins), reducing intestinal permeability

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The compound has been evaluated in multiple randomised, placebo-controlled trials and has generated results that have been published in leading peer-reviewed journals including the New England Journal of Medicine, The Lancet, and Nature Medicine

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For many patients, this biological change is profound: meals that previously triggered constant grazing now satisfy them for hours, making dietary adherence feel natural rather than forced