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In alcohol tests in which Ex4, liraglutide, or dulaglutide was injected repeatedly, there was no development of tolerance toward the GLP-1R agonists tested (Suchankova et al., 2015

However, no large-scale human clinical trials have been completed, so long-term safety data in humans remains limited

174 Currently, Eli Lilly has initiated a Phase III development program to further investigate the efficacy and safety of orforglipron in treating obesity, overweight, and T2DM

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