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doi:10.1152/japplphysiol.00945.2010 Staresinic M, Sebecic B, Patrlj L, et al

Some prescription IBD medications, such as sulfasalazine and methotrexate, may interfere with the absorption of folic acid

DSIP promotes sleep by interacting with various brain regions that govern sleep, such as the hypothalamus and the brainstem (Kastin & Akerstrom, 2003)

Homocysteine toxicity, altered folate homeostasis, and direct neuronal damage are considered to be the pathogenic mechanisms of MTX neurotoxicity [164]