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Compared to other growth factors, compelling evidence suggests that IGF-1 plays a pivotal role in enhancing the regenerative potential of injured tendons

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Additionally, Biochanin A (BCA) can reduce intracellular iron levels by suppressing TfR1 activity and enhancing the expression of ferroportin (FPN), thereby alleviating mitochondrial damage and chondrocyte apoptosis induced by iron overload ( Iron chelators represent an effective intervention for patients with excessive TfR1 expression, binding circulating and intracellular iron for excretion via urine or bile, thereby reducing ferroptosis (Rodrigues de Morais and Gambero, 2019)

This suggests that the protective association may be more pronounced in conditions closely linked with metabolic dysfunction and inflammation rather than autoimmune diseases more broadly, Ibis said

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