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We generated GGT1 knockdown cell lines using CRISPRi approaches and GGT1 KO cell lines (polyclonal and single-cell clones) using CRISPRCas9 approaches

The researchers injected conjugated gold nanoparticles into mice that had been given an excessive dose of acetaminophen (APAP)

4ah) submitted to the NCBI Sequence Read Archive database were GSE248829 and PRJNA1456226, respectively

Isoliquiritigenin inhibits NLRP3 inflammasome activation with CAPS mutations by suppressing caspase-1 activation and mutated NLRP3 aggregation

Lys105 is a GSH and enzyme activator in the GSSCys assay In a first set of experiments, we analysed the effects of the Lys105 replacements on the steady-state kinetics at variable GSSCys and GSH concentrations