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Evidence from experimental models indicates that oxidative stress and hypertension have a causal relationship [244, 245]

Pathways of note that have been shown to promote OPC differentiation through cannabinoid receptors are the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) and mammalian target of rapamycin (mTOR), ERK/MAPK, and Rat sarcoma (Ras) homolog family member A/Rho-associated protein kinase (RhoA/ROCK

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Peer review Peer review information Nature Communications thanks Stephen Bourke, Rute Vieiraand and the other anonymous reviewer(s) for their contribution to the peer review of this work

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