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( A L ) Plasma concentrations of insulin ( A ), GLP-1 (active) ( B ), leptin ( C ), PYY ( D ), C-peptide 2 ( E ), GIP (total) ( F ), amylin (active) ( G ), glucagon ( H ), PP ( I ), ghrelin ( J ), resistin ( K ), and secretin ( L ) in 15- to 22-week-old ad libitum chow-fed male and female WT C57BL/6J and Bbs5 / mice ( n = 9 per strain)

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GH and IGF-1 are surrogate biomarkers they tell you the drug engages its axis, not that it produces any clinical benefit or is safe over the long term