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Under oxidative stress conditions, NRF2 separates from Keap1 and activates the expression of downstream target genes containing antioxidant response elements (ARE), such as iron heavy chain protein (FTH1) and iron light chain protein (FTL), promoting GSH synthesis and regenerating NADPH to exceed ROS production (36, 83)

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Khan AU, Delude RL, Han YY, et al

It has also been reported by Lim et al published in Cancer research , that glutathione (GSH) deficiency is related to premature ovarian aging and even ovarian cancer