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The most common side effects include: Gastrointestinal issues, like constipation, diarrhea, nausea and vomiting, due to the drugs effect on digestion Cosmetic changes, including hair loss, muscle loss, loose or sagging skin, and more pronounced wrinkles (The term Ozempic face has been used to describe these changes, but the effects are due to rapid weight loss, not the medications themselves.) Increased heart rate: Several GLP-1s are beneficial to heart health, but some patients report a slightly elevated heart rate while on them

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