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10.1136/annrheumdis-2020-217871 84

Additionally, tetracyclines exert pleiotropic immuno-modulatory effects that may be able to rebalance immune homeostasis in critically ill patients

The ERGIC can then serve as a membrane source for LC3 lipidation, which is dependent on the adaptor protein WIPI2 and ATG5 but does not require ULK1 or VPS34, indicating that this non-canonical STING-dependent induction of autophagy can skip early steps of the canonical autophagy mechanism (141)

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