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GLP-1 medications like semaglutide also slow gastric emptying, which reduces the thermic effect of foodthe calories your body burns during digestion

The effects of disruption of genes for peroxiredoxin-2, glutathione peroxidase-1, and catalase on erythrocyte oxidative metabolism

A previous study indicated that NRF2 is an important and novel transcriptional regulator of ferroptosis in hepatocellular carcinoma (HCC) cells, and NRF2 activation can inhibit ferroptosis in HCC cells [67,68,69]

The preclinical data creates false confidence that may not translate to humans

You and your provider can try to determine whether semaglutide is the cause of your heartburn and discuss possible solutions