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Besides, there are FAP + THY1 fibroblasts selectively mediate bone and cartilage damage with little effect on inflammation, and FAP + THY1 + fibroblasts resulted in a more severe and persistent inflammatory arthritis, with minimal effect on bone and cartilage in RA ( + THY1 + FLSs and promote the secretion of anti-inflammatory factors by FAP + THY1 + FLSs, thereby inhibiting FAP + THY1 FLS proliferation and migration inhibiting RA damage ( 3.2 Synovial tissue macrophages Different subpopulations of STMs exist in the human synovium, and different STMs subpopulations have different homeostatic and regulatory inflammatory functions, and STM have a key role in restoring joint homeostasis (Kurowska-Stolarska and Alivernini, 2017