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FSP1 catalyzes the reduction of CoQ10 to CoQ10H 2 , a lipophilic antioxidant that neutralizes PL-OOHs and halts lipid peroxidation, thereby suppressing ferroptosis independently of GPX4 ( 2 that scavenges ROS and phospholipid hydroperoxides (PL-OOHs) within mitochondria and prevents ferroptosis (Mao et al., 2021