We were able to single out a protein, Med14, whose activation downstream of GLP-1 helps reprogram pancreatic beta cell gene expression to improve the cells viability and insulin production. Often simply called GLP-1 drugs or GLPs, glucagon-like peptide-1 receptor agonists work by mimicking a hormone our bodies naturally make
[19] Adverse effects include nasopharyngitis, headache, nausea, heart failure, hypersensitivity, and skin reactions
Monitoring schedule When combining therapies, more frequent monitoring helps catch issues early: Month 1: Baseline labs including hormones (estradiol, progesterone, testosterone, FSH), metabolic panel, lipids, thyroid function, and HbA1c
In most studies, GIP remains ineffective and may even stimulate glucagon secretion, which naturally is counterproductive
Thorel et al., 2010)