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Description

335,336 First reported as the first reversible METAP inhibitor (METAPi) in 2003, LAF389 is a natural benzimide compound with dual METAP 1i and METAP 2i activities

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These G protein-coupled receptors (Waldhoer et al., 2004) undergo conformational changes upon heroin binding, thereby inhibiting adenylate cyclase activity, reducing cAMP production (Tedford and Zamponi, 2006), and subsequently impairing neuronal signaling (Figure 3)

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