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In vivo studies done in rhesus monkeys reflecting the relationship between antibody response and increased viremia to different DENV serotypes has been added to further evidence to the phenomenon of ADE 94,103,118,121,122

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3.6.3 Uncertainty management and the clinical pathway Beyond aggregate effects, the Bayesian framework offers a more intuitive representation of the potential range of individual response through posterior predictive distributions, effectively transforming heterogeneity from a statistical artifact into a tool for managing clinical uncertainty