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These non-enzymatic antioxidants, whether from diet or synthesized for therapy, vary in effectiveness against human cancer, showing both successes and failures in use [62,63,64]

To ensure the supplement's absorption and bioavailability, it is advisable to take 500 micrograms three times a day, for a total of 1500 micrograms of either methylcobalamin or 5' adenosylcobalamin

However, these cardiovascular applications require particularly careful consideration given the potential risks associated with promoting angiogenesis in patients who may have undiagnosed malignancies or other conditions where angiogenesis promotion could be detrimental