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During deep sleep: Growth hormone secretion peaks, driving tissue repair and muscle recovery The brains glymphatic system clears metabolic waste products, including proteins associated with neurodegeneration Cortisol levels reach their daily minimum, allowing the adrenal system to reset Immune function regenerates Cellular repair mechanisms run at maximum efficiency Most adults spend less time in deep sleep than optimal, and this deficit increases with age, stress, alcohol consumption, and certain medications

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Since GSTO1 overexpression has been implicated in drug resistance, particularly to platinum compounds 7,18,19 , we tested the effects of GSTO1 inhibitors in combination with cisplatin in HCT116 cells

Epidemiology of anxiety disorders: from surveys to nosology and back