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epididymis: 10 g

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Once inside, cholesterol translocates from the plasma membrane to the ER, where it is esterified by acyl coenzyme A-cholesterol acyltransferase 2 (ACAT2, also known as sterol O-acyltransferase, SOAT2) into cholesteryl esters (CEs)

The microdosing schedule may be prescribed as follows: Weeks 14: 1.0 mg once weekly Weeks 58: 1.5 mg once weekly Weeks 912: 2.0 mg once weekly Week 13 and beyond: Transition to the standard 2.5 mg dose, then proceed with the standard escalation plan