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Compounding pharmacies prepare tirzepatide formulations according to their own protocols, which must comply with USP 795 (non-sterile) or USP 797 (sterile compounding) guidelines
Furthermore, its short half-life of less than 3 h (Min et al., 2025) necessitates twice-daily injections to maintain efficacy, which can be a limiting factor for long-term patient adherence
A licensed provider determines eligibility
How to use tirzepatide ODT For those who had access to tirzepatide ODT before the compounding ban, or who may still have remaining supply, understanding proper administration technique is important for maximizing whatever absorption the formulation can achieve
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