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Animal-to-human amount translation is not straightforward and requires allometric scaling, and human pharmacokinetics, safety, and efficacy remain uncharacterized in published literature

however, concentrations 0.01% levels of heat shock protein (hsp) 70 were elevated, indicating a stress response 52,117

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A lack of integration also plays a role, with poor screening for substance use disorders in both mental health and primary care settings, along with significant provider shortages in rural areas