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In the normal renal function group, one participant had a clinically significant vital sign abnormality (increased blood pressure) and one had a clinically significant ECG abnormality, with both reported as resolved mild TEAEs

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Weve all heard it before, but losing weight requires a combination of healthy eating and physical activity with the goal of burning more calories than consumed

Conclusions and Lessons Learned The potential of DPP-4 inhibition as a glucose-lowering concept has now been explored for more than 25 years and it is more than 10 years since several DPP-4 inhibitors were introduced to the market (Figure 1)