The primary outcome, which was a composite of CV death, non-fatal myocardial infarction, non-fatal stroke, or hospitalization for unstable angina (4-point MACE), achieved non-inferiority (p 7.2%), age, sex, body mass index, duration of diabetes, or geographical region
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Unlike fat tissue, which is metabolically flexible and responsive to caloric changes in both directions, bone mineral density lost during rapid weight loss requires active, sustained intervention to rebuild - and even with intervention, recovery is neither guaranteed nor complete