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Over time, this can lead to: Loss of lean body mass and lower resting metabolic rate Reduced protein intake , making it harder to maintain muscle Micronutrient deficiencies , particularly vitamin D, calcium, magnesium, and B-vitamins Lower energy levels and slower recovery from illness or exercise (Mozaffarian, 2025) Gastrointestinal side effects can make the picture even more complex

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Poole R, Ballantyne A (2014) Apremilast: first global approval

Its an exciting moment after decades of unsuccessful attempts to find effective treatments for people living with obesity. - Juan Franco, co-lead researcher from Heinrich Heine University Dsseldorf, Germany

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