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In CKD patients, even though anemia develops primarily as a result of the decreased lifespan of RBCs caused by the low production of erythropoietin and iron deficiency, eryptosis seems to be a fundamental contributing factor [244,245,246]
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Promote renal calcium reabsorption Renal tubular calcium transport: upregulate the expression of renal tubular calcium channel (TRPV5), reduce urinary calcium excretion by 30% -40%, increase blood calcium concentration, and increase bone calcium deposition Evidence from preclinical studies on AOD 9604 bone protection (animal experiments) Postmenopausal osteoporosis (OVX rat model) Experimental Design: Animal: 6-month-old female SD rats underwent bilateral ovariectomy (OVX) to establish a postmenopausal osteoporosis model
It is an active and complex battlefield that has been fighting these wars for years