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Additionally, increased GGCT2;1 mRNA and GGCT activity favor adequate GSH turnover by recycling Glu, as demonstrated by isotopic labeling studies in GGCT2;1 overexpression lines [137]

AA is a basic precursor of numerous lipid-based signaling molecules and can be further transformed by cyclooxygenases (COX), lipoxygenases (LOX) and cytochrome p450 (CYP450) to form eicosanoids, further influencing redox balance and inflammation by engaging specific receptors 93

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