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A significant subset of people living with HIV (PLWH) who achieve virological suppression fail to restore normal CD4+ T cell counts, a condition known as incomplete immune reconstitution or immunological non-response (INR)

Patients should never double up on doses or take extra medication to compensate for missed doses, as this increases the risk of adverse effects without providing additional therapeutic benefit

However, its clinical application has been limited by dose-dependent gastrointestinal toxicity observed in later phase I and II clinical trials

2.2 Key technological milestones in nanoencapsulation for nutraceuticals The development of nanoencapsulation technologies in nutraceuticals has progressed through several key phases, reflecting a transition from basic protection of ingredients to advanced, multifunctional delivery systems

However, its important to keep a balanced perspective