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In the wider literature, established evidence from randomised controlled trials, albeit in non-CKD populations, generally support GLP-1 RAs (notably once-daily semaglutide over 52 weeks) for HbA1c and weight benefits, owing to the strength of evidence demonstrating their role in body weight, glycaemic and blood pressure reduction [25, 27]
New medications entering clinical trials and approaching approval include triple agonists like retatrutide , combination therapies like CagriSema , oral formulations that eliminate the need for injections, and even transdermal GLP-1 patches
This is good for your skin, and for your liver and health
Weight loss can include some loss of lean mass if protein intake is too low
Besides GLPs, DPP-IV is able to cleave some chemokines and cytokines such as IL-3, and granulocyte-macrophage colony-stimulating factor (GM-CSF), thereby regulating the immune responses (Kameoka et al
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