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While GLP-1 receptor agonists were developed to treat type 2 diabetes, many have demonstrated significant weight loss or weight maintenance effects

The authors note the meta-analysis did not include studies of lifestyle interventions and bariatric surgery, reducing the degree to which different weight loss approaches could be compared within the context of the study

Lowering the dose might help reduce symptoms without affecting how well the treatment works

3 However, gastrointestinal side effects increased with high dosage

The majority of reported events occurred in patients who experienced gastrointestinal reactions leading to dehydration such as nausea, vomiting, or diarrhea