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Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases

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Current evidence suggests several contributing mechanisms, including the biological activation of melanocytes, accumulation of melanin and melanosomes in the epidermis and dermis, increased mast cell numbers, photo-induced elastic fiber damage, alterations in the basement membrane, and enhanced vascularization 2,3,4,5,6,7