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Other documented findings include a tendency toward IGF-1 receptor desensitization with prolonged, continuous exposure, transient fluid retention in early study phases, and at supraphysiological exposure levels examined in some research acromegaly-like tissue changes

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Given that the nomogram cannot be safely used for risk assessment in MR and ER overdose, it is unclear whether the documented risks for MR acetaminophen extend to the ER formulation

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Ciliary neurotrophic factor (CNTF): new facets of an old molecule for treating neurodegenerative and metabolic syndrome pathologies

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