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Our findings demonstrated elevated hypothalamic GLP-1R expression (Figure 4A) and preserved responsiveness to the acute GLP-1RA exendin-4 in Bbs5 / mice (Figure 4, LN), making them a compelling candidate for addressing BBS-associated metabolic dysfunction

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They originate from the same pluripotent stem cells as well as the other cell lines of the intestinal epithelium

Zheng RH, Bai XJ, Zhang WW, Wang J, Bai F, Yan CP, James EA, Bose HS, Wang NP, Zhao ZQ

The delivery itself was also complicated by shoulder dystocia (when one or both shoulders dont easily clear the birth canal), but neither of those issues could directly be linked to semaglutide use