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We used bilaterally implanted twisted bipolar electrodes, and in general the approach was inspired by the paradigms used for pre-clinical non-human primate studies and the treatment of human PD [64]

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Notably, AHCY is the only reversible enzyme in the methionine cycle and as such is a key regulator of the SAM to SAH molar ratio, commonly referred to as the methylation index or indicator of methylation capacity. [67] When SAH and homocysteine concentrations increase faster than methionine regeneration, SAM utilizing enzymes are inhibited by SAH and the SAM concentrations then act in a feed-forward mechanism to allosterically activate the B6-dependent cystathionine beta-synthase (CBS) which metabolizes homocysteine through the transsulfuration pathway and allows the methionine cycle to continue [68,69]

And so you end up getting this causal between, this causation between stress, inflammation and then depression

Heavy Metals and Human Health: Possible Exposure Pathways and the Competition for Protein Binding Sites