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Clinical evidence suggests that zinc deficiency can impair wound healing as low serum zinc levels correlate with poor healing outcomes, including infection and dehiscence in patients undergoing hip replacement surgeries [22]

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Simultaneously, the activation of plaque macrophages by CD4 + T lymphocytes through CD40LCD40 signaling amplifies pro-inflammatory cytokine secretion, promotes macrophage polarization towards the M1 phenotype, and recruits immune cells, collectively perpetuating plaque instability