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Gastrointestinal side effects, including nausea, constipation, diarrhea, and vomiting, were the most common complaint in both groups and were generally mild to moderate, occurring mostly during the dose escalation phase.[1] Injection site reactions were more common with tirzepatide (8.6% vs

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However, erythrocyte ChE activity was inhibited at all doses, and the highest dose produced signs of intoxication (Hazelwood et al., 1979)