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The published research literature for Semaglutide includes large-scale outcome data in body composition models, cardiovascular outcome research (SUSTAIN and STEP trial series), renal function studies, and emerging neurological research examining GLP-1R agonism in Alzheimer's and Parkinson's disease models (the FLOW and EVOKE trial programmes)

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The review traced the developmental history of GLP-1 research from the identification of the proglucagon gene in 1982 through to the contemporary landscape of GLP-1-based therapeutics across obesity, cardiovascular disease, NAFLD, neurodegeneration, and cancer biology

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