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10.1016/j.phymed.2024.155554 Summary Keywords Chinese medicine, natural metabolites, CVDs, flavonoids, alkaloids, saponins Citation Liu X, Zhang W, Miao X and Hu Y (2025) Natural metabolites used in traditional Chinese medicine for cardiovascular diseases: pharmacological mechanisms, evidence, and future directions

Once liver function normalizes, therapeutic paracetamol can be resumed, with the discontinuation of NAC guided by the toxicologists recommendation [28]

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Oxidative stress is caused by reactive oxygen/nitrogen species (ROS/RNS), as well as free radicals that can cause lipid peroxidation, DNA damage, protein oxidation, and other undesirable adverse reactions with various cellular components [9,10]